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Table 2 Summary of MRI changes stratified by sex

From: Brain iron accumulation in neurodegenerative disorders: Does air pollution play a role?

Male

Female

Structure

Air vs Fe

Structure

Air vs Fe

Diffusion tensor imaging changes

 + Olfactory Bulb

Mean: − 5.3%

 + Olfactory Bulb

Mean: 5.0%

 

Radial: − 4.9%

 

Radial: 4.8%

 

Axial: − 5.9%

 

Axial: 5.3%

Olfactory areas

Mean: − 4.2%

Anterior olfactory nucleus

Axial: 5.4%

 

Axial: -4.8%

  

Hippocampal commissures

Radial: − 4.4%

  

Fractional anisotropy changes

 + Posterior amygdalar nucleus

 − 11.3%

  

Hypoglossal nucleus

 − 10.7%

  

Pretectal region

 − 10.3%

  

Medial preoptic nucleus

8.9%

  

Nucleus accumbens

7.9%

  

Basomedial amygdalar nucleus

 − 7.0%

  

Subicular region

 − 6.6%

  

Cortical amygdalar Zones

 − 6.4%

  

Fimbria

 − 6.1%

  

Cranial nerves

 − 5.6%

  

Trigeminal nerve

 − 5.4%

  

Striatum ventral region

4.1%

  

CA1

 − 2.4%

  

Volumetric changes

Substantia Nigra Compact part

8.0%

 + Medial geniculate complex, ventral part

 − 6.2%

Trigeminal nerve

− 6.0%

Vestibulocerebellar Nucleus

5.5%

Midline group of the dorsal thalamus

5.2%

Lateral amygdalar nucleus

 − 3.6%

Optic tract and Chiasm

 − 4.7%

Medulla sensory related

2.4%

Posterior complex of the thalamus

4.1%

  

Spinal vestibular nucleus

3.6%

  

 + Geniculate group, dorsal thalamus

3.5%

  

Epithalamus

 − 3.0%

  

Bed nuclei of the stria terminalis

 − 2.1%

  
  1.  + Structures which appeared significant in the 2-Way ANOVA analysis, considering sex and exposure together. For all entries, uncorrected p-values is < 0.05 and estimated Cohen’s F is 1.73. Negative (−) % change signifies that Air is larger and positive (+) % change signifies that Fe is larger. Volumetric findings were controlled by brain volume of each specimen, thus is normalized volume