Figure 6
Energy metabolism response to ICV infusion of IMD- 0354 in KKay mice exposed to PM2.5. O2 consumption (A), CO2 production (B), respiratory exchanging ratio (C) and heat production (D) of mice measured by indirect calorimetry over a 24 hrs period (from 10:00 am to 10:00 am the next day) after 4 wks of PM2.5 exposure and IKKβ inhibitor treatment. When RM (repeated measures adjusting for time) analysis was applied: ***P < 0.001 compared to FA-CON group; #P < 0.05, ###P < 0.001 when compared PM-IMD group with PM-CON group. When Avg (the average over time followed by linear regression) was applied, &P < 0.05 compared to FA-CON group. n = 6 per group.